drugset / Trial / NCT00224549
PHARES Study: Management of Resistant Hypertension
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to assess the efficacy of two different treatment regimens for treating resistant hypertension previously uncontrolled with at least 3 antihypertensive treatments. The study hypothesis is that these two regimens (one based on increasing diuretics and the other based on increasing renin angiotensin system blockage) may not differ in terms of efficacy.
Timeline
- Start
- 2005-04
- Primary completion
- 2009-08
- Completion
- 2009-08
Publications
- Mendes M, Dubourg J, Blanchard A, Bergerot D, Courand PY, Forni V, Frank M, Bobrie G, Menard J, Azizi M. Copeptin is increased in resistant hypertension. J Hypertens. 2016 Dec;34(12):2458-2464. doi: 10.1097/HJH.0000000000001106.
- Frank M, Peyrard S, Bobrie G, Azizi M. Method of mean value calculation as an additional source of variability in ambulatory blood pressure measurement. Am J Hypertens. 2010 Jul;23(7):725-31. doi: 10.1038/ajh.2010.47. Epub 2010 Mar 25.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Amlodipine | Other / unclassified | 5 mg | — |
| Background | Hydrochlorothiazide | Unknown | 12.5 mg | — |
| Background | Irbesartan | Small molecule | 300 mg | — |