Treatment of Bacterial Vaginosis With Oral Tinidazole

Summary

The purpose of this study is to confirm the safety and efficacy of oral tinidazole for the treatment of bacterial vaginosis.

Timeline

Start

2005-01

Primary completion

2007-06

Completion

2007-06

Outcome

Met primary endpoint

paper Superior efficacy was demonstrated by tinidazole for the 1 g once daily for 5 days regimen (36.8% cured, P<.001 PMID 17666604 ↗

paper and for the 2 g once daily for 2 days regimen (27.4% cured, P<.001, number needed to treat 4.5), when compared with placebo (5.1% cured) in the primary endpoint analysis. PMID 17666604 ↗

Publications

• Livengood CH 3rd, Ferris DG, Wiesenfeld HC, Hillier SL, Soper DE, Nyirjesy P, Marrazzo J, Chatwani A, Fine P, Sobel J, Taylor SN, Wood L, Kanalas JJ. Effectiveness of two tinidazole regimens in treatment of bacterial vaginosis: a randomized controlled trial. Obstet Gynecol. 2007 Aug;110(2 Pt 1):302-9. doi: 10.1097/01.AOG.0000275282.60506.3d.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	tinidazole	Small molecule	1 g	Oral
Subject	tinidazole	Small molecule	2 g	Oral

Indications