Thyroxine Replacement in Organ Donors

Phase 1/2 Completed 34 enrolled London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

RandomizedSingle-groupQuadruple-blindTreatment

Summary

To compare oral versus intravenous administration of thyroid hormone: 1) for reversibility of hemodynamic instability in organ donors, and, 2) the pharmacokinetics of oral vs iv thyroid administration

Timeline

Start: 2004-12
Primary completion: 2009-05
Completion: 2010-10

Publications

Background Novitzky D, Cooper DK, Chaffin JS, Greer AE, DeBault LE, Zuhdi N. Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient. Transplantation. 1990 Feb;49(2):311-6. doi: 10.1097/00007890-199002000-00017.
Sharpe MD, van Rassel B, Haddara W. Oral and intravenous thyroxine (T4) achieve comparable serum levels for hormonal resuscitation protocol in organ donors: a randomized double-blinded study. Can J Anaesth. 2013 Oct;60(10):998-1002. doi: 10.1007/s12630-013-0004-x. Epub 2013 Jul 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Levothyroxine	Other / unclassified	2 ug/kg	Oral

Indications

No indication recorded.