drugset / Trial / NCT00239694
PPV: Pneumococcal Polysaccharide Vaccine in Older Adults
Non-randomizedCrossoverOpen-labelTreatment
Summary
The purpose of this study is to measure how long the improvement in the immune system lasts in older people after they have been vaccinated, and to examine the immune response in older people who get vaccinated a second time.
Timeline
- Start
- 2001-04
- Primary completion
- 2012-08
- Completion
- 2012-08
Publications
- Background Hedlund J, Ortqvist A, Konradsen HB, Kalin M. Recurrence of pneumonia in relation to the antibody response after pneumococcal vaccination in middle-aged and elderly adults. Scand J Infect Dis. 2000;32(3):281-6. doi: 10.1080/00365540050165929.
- Background Musher DM, Luchi MJ, Watson DA, Hamilton R, Baughn RE. Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption of serum with non-type-specific cell wall polysaccharide. J Infect Dis. 1990 Apr;161(4):728-35. doi: 10.1093/infdis/161.4.728.
- Background Hilleman MR, Carlson AJ Jr, McLean AA, Vella PP, Weibel RE, Woodhour AF. Streptococcus pneumoniae polysaccharide vaccine: age and dose responses, safety, persistence of antibody, revaccination, and simultaneous administration of pneumococcal and influenza vaccines. Rev Infect Dis. 1981 Mar-Apr;3 Suppl:S31-42. doi: 10.1093/clinids/3.supplement_1.s31.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Meningococcal Vaccine | Vaccine | — | — |
| Subject | Prevnar 13 | Vaccine | — | — |
Indications
No indication recorded.