Efficacy and Safety of FTY720 in de Novo Adult Renal Transplant Recipients

Summary

This study will evaluate the safety and efficacy of FTY720 combined with cyclosporine and corticosteroids in patients receiving a kidney transplant.

Timeline

Start

2004-11

Primary completion

2006-11

Completion

—

Outcome

Met primary endpoint

paper The primary endpoint was superior in Group 1 (24%) and statistically noninferior in Group 2 compared to Group 3 PMID 17984842 ↗

paper (24.1% vs. 29.2% vs. 39.4%; P=0.025 and 0.0039, respectively). PMID 17984842 ↗

Publications

• Results Tedesco-Silva H, Szakaly P, Shoker A, Sommerer C, Yoshimura N, Schena FP, Cremer M, Hmissi A, Mayer H, Lang P; FTY720 2218 Clinical Study Group. FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study. Transplantation. 2007 Oct 15;84(7):885-92. doi: 10.1097/01.tp.0000281385.26500.3b.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fingolimod	Small molecule	2.5 mg	—
Subject	Fingolimod	Small molecule	5 mg	—

Indications

No indication recorded.