drugset / Trial / NCT00242463
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
Phase 2
Terminated
20 enrolled
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
RandomizedSingle-groupDouble-blindTreatment
Summary
This prospective, double-blinded study will determine the feasibility of determining the efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in malnourished ICU patients.The data from this study will also enable us to prepare a future grant proposal with a calculated sample size necessary to demonstrate an improvement in clinical outcome.
Timeline
- Start
- 2005-10
- Primary completion
- 2007-10
- Completion
- 2007-10
Publications
- Background Chang DW, DeSanti L, Demling RH. Anticatabolic and anabolic strategies in critical illness: a review of current treatment modalities. Shock. 1998 Sep;10(3):155-60. doi: 10.1097/00024382-199809000-00001.
- Background Johansen KL, Mulligan K, Schambelan M. Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. JAMA. 1999 Apr 14;281(14):1275-81. doi: 10.1001/jama.281.14.1275.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nandrolone | Other / unclassified | 25 mg | Intramuscular |
| Subject | Nandrolone | Other / unclassified | 50 mg | Intramuscular |