Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors

Summary

This phase I trial is studying the side effects and best dose of vorinostat and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, such as vorinostat and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

Timeline

Start

2005-11

Primary completion

2011-08

Completion

—

Drugs

Indications

No indication recorded.