drugset / Trial / NCT00243880
Neuroprotection With Statin Therapy for Acute Recovery Trial (Neu-START)
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this dose escalation study is to evaluate the use of lovastatin for the treatment of acute ischemic stroke.
Timeline
- Start
- 2005-09
- Primary completion
- 2008-05
- Completion
- 2008-05
Publications
- Background Elkind MS, Sacco RL, MacArthur RB, Fink DJ, Peerschke E, Andrews H, Neils G, Stillman J, Corporan T, Leifer D, Cheung K. The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke. Int J Stroke. 2008 Aug;3(3):210-8. doi: 10.1111/j.1747-4949.2008.00200.x.
- Results Elkind MS, Sacco RL, Macarthur RB, Peerschke E, Neils G, Andrews H, Stillman J, Corporan T, Leifer D, Liu R, Cheung K. High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART). Cerebrovasc Dis. 2009;28(3):266-75. doi: 10.1159/000228709. Epub 2009 Jul 16.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lovastatin | Small molecule | 1 mg/kg | — |
| Subject | Lovastatin | Small molecule | 3 mg/kg | — |
| Subject | Lovastatin | Small molecule | 6 mg/kg | — |
| Subject | Lovastatin | Small molecule | 8 mg/kg | — |
| Subject | Lovastatin | Small molecule | 10 mg/kg | — |