Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Phase 1 Completed 26 enrolled University of California, San Francisco National Institute of Neurological Disorders and Stroke (NINDS) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.

Timeline

Start: 2004-07
Primary completion: 2008-10
Completion: 2008-10

Publications

Results Frenzel T, Lee CZ, Kim H, Quinnine NJ, Hashimoto T, Lawton MT, Guglielmo BJ, McCulloch CE, Young WL. Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance. Cerebrovasc Dis. 2008;25(1-2):157-63. doi: 10.1159/000113733. Epub 2008 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Doxycycline	Small molecule	50 mg	—
Comparator	Minocycline	Small molecule	50 mg	—

Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

Summary

Timeline

Publications

Drugs

Indications