Magnetic Resonance Imaging Study of Geriatric Depression

Completed 43 enrolled Mclean Hospital National Alliance for Research on Schizophrenia and Depression · collab Pfizer · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.

Timeline

Start: 2004-11
Primary completion: 2008-08
Completion: 2008-08

Publications

Harper DG, Joe EB, Jensen JE, Ravichandran C, Forester BP. Brain levels of high-energy phosphate metabolites and executive function in geriatric depression. Int J Geriatr Psychiatry. 2016 Nov;31(11):1241-1249. doi: 10.1002/gps.4439. Epub 2016 Feb 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sertraline	Small molecule	200 mg	Oral

Magnetic Resonance Imaging Study of Geriatric Depression

Summary

Timeline

Publications

Drugs

Indications