The Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) Protocol

Summary

The purpose of the study was to evaluate the ability of a maintenance dosage regimen of infliximab to achieve and sustain at least 40% improvement from baseline in the total joint count in patients with active Rheumatoid Arthritis (RA) during methotrexate tapering.

Timeline

Start

2001-12

Primary completion

—

Completion

2003-11

Publications

• Results Fleischmann RM, Cohen SB, Moreland LW, Schiff M, Mease PJ, Smith DB, Keenan G, Kremer JM; iRAMT Study Group. Methotrexate dosage reduction in patients with rheumatoid arthritis beginning therapy with infliximab: the Infliximab Rheumatoid Arthritis Methotrexate Tapering (iRAMT) trial. Curr Med Res Opin. 2005 Aug;21(8):1181-90. doi: 10.1185/030079905X53261.

Drugs

Indications