Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIV

Summary

The purpose of this study is to test whether chronic administration of the drug acipimox will improve hyperlipidemia and insulin sensitivity among HIV infected patients experiencing highly active antiretroviral therapy (HAART) associated metabolic disturbances.

Timeline

Start

2002-09

Primary completion

—

Completion

2006-08

Outcome

Met primary endpoint

paper compared with an increase from 290 to 348 mg/dl in the placebo group (P = 0.01). PMID 16940448 ↗

Publications

• Results Hadigan C, Liebau J, Torriani M, Andersen R, Grinspoon S. Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. J Clin Endocrinol Metab. 2006 Nov;91(11):4438-44. doi: 10.1210/jc.2006-1174. Epub 2006 Aug 29.

Drugs

Indications