Study of PET Scans and Serotonin in Hot Flashes Treatment

Terminated 5 enrolled Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine in a preliminary manner whether successful therapy of hot flashes can be associated with changes in the serotonin transporter in the brain. The serotonin transporter is important in delivering serotonin into certain portions of the brains (serotonin is a chemical that is important in the control of body temperature, mood, sleep, and other functions).

Timeline

Start: 2005-10
Primary completion: 2007-07
Completion: 2008-04

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Paroxetine	Small molecule	12.5 mg	Oral
Subject	conjugated estrogens	Other / unclassified	0.625 mg	Oral

Indications

No indication recorded.