drugset / Trial / NCT00253929
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
Completed
100 enrolled
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development · collab
Non-randomizedParallel-groupOpen-labelDiagnostic
Summary
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors. taken together these effects protect against ischaemia-reperfusion injury of (myocardial)muscles and agsinst the development of atherosclerosis. Genetic variations in genes encoding for adenosine receptors or for enzymes involved in the formation or breakdown of adenosine could potentially modulate these effects. In this study, we aim to determine the functional effects of two frequent genetic polymorphisms in the adenosine receptor and AMPdeaminase (involved in the formation of adenosine) on the vascular effects of adenosine.
Timeline
- Start
- 2005-11
- Primary completion
- —
- Completion
- 2006-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Adenosine | Small molecule | — | Other |
| Subject | Caffeine | Small molecule | — | Other |
| Background | Acetylcholine | Small molecule | — | Other |
| Background | Sodium Nitroprusside | Unknown | — | Other |
Indications
No indication recorded.