A Randomized Placebo Controlled Study to Show That Rasagiline May Slow Disease Progression for Parkinson's Disease

Summary

A 2 phase study to evaluate disease progression in Parkinson's disease patients taking rasagiline

Timeline

Start

2005-11

Primary completion

2008-04

Completion

2009-06

Outcome

Mixed primary results

paper Early-start treatment with rasagiline at a dose of 1 mg per day met all end points in the primary analysis PMID 19776408 ↗

paper All three end points were not met with rasagiline at a dose of 2 mg per day PMID 19776408 ↗

Publications

• Kirkham EM, Ishman S, Garetz S, Baldassari CM, Mitchell RB, Liu C, Tapia IE, Elden LM, Hassan F, Ibrahim S, Ross K, Cen M, Wang R, Redline S, Chervin RD. Progression of mild sleep-disordered breathing in children managed with watchful waiting. J Clin Sleep Med. 2026 Jul 7;22(1):106. doi: 10.1007/s44470-026-00082-y.
• Masellis M, Collinson S, Freeman N, Tampakeras M, Levy J, Tchelet A, Eyal E, Berkovich E, Eliaz RE, Abler V, Grossman I, Fitzer-Attas C, Tiwari A, Hayden MR, Kennedy JL, Lang AE, Knight J; ADAGIO investigators. Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study. Brain. 2016 Jul;139(Pt 7):2050-62. doi: 10.1093/brain/aww109. Epub 2016 May 13.
• Smith KM, Eyal E, Weintraub D; ADAGIO Investigators. Combined rasagiline and antidepressant use in Parkinson disease in the ADAGIO study: effects on nonmotor symptoms and tolerability. JAMA Neurol. 2015 Jan;72(1):88-95. doi: 10.1001/jamaneurol.2014.2472.
• Rascol O, Fitzer-Attas CJ, Hauser R, Jankovic J, Lang A, Langston JW, Melamed E, Poewe W, Stocchi F, Tolosa E, Eyal E, Weiss YM, Olanow CW. A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol. 2011 May;10(5):415-23. doi: 10.1016/S1474-4422(11)70073-4. Epub 2011 Apr 7.
• Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston W, Melamed E, Poewe W, Stocchi F, Tolosa E; ADAGIO Study Investigators. A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med. 2009 Sep 24;361(13):1268-78. doi: 10.1056/NEJMoa0809335.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rasagiline	Small molecule	1 mg	—
Subject	Rasagiline	Small molecule	2 mg	—

Indications