drugset / Trial / NCT00257127
Immune System Function Following Vaccination in HIV Infected Children Taking Anti-HIV Drugs
Completed
101 enrolled
National Institute of Allergy and Infectious Diseases (NIAID)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to determine immune system function following vaccination in HIV-infected children currently taking anti-HIV drugs. To test the effectiveness of prior vaccination, patients in this study will receive booster shots of one of two pneumococcal vaccines, a hepatitis B vaccine, and a measles vaccine.
Timeline
- Start
- 2006-02
- Primary completion
- 2006-08
- Completion
- 2006-08
Publications
- Background Obaro SK, Pugatch D, Luzuriaga K. Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children. Lancet Infect Dis. 2004 Aug;4(8):510-8. doi: 10.1016/S1473-3099(04)01106-5.
- Abzug MJ, Song LY, Levin MJ, Nachman SA, Borkowsky W, Pelton SI; International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams. Antibody persistence and immunologic memory after sequential pneumococcal conjugate and polysaccharide vaccination in HIV-infected children on highly active antiretroviral therapy. Vaccine. 2013 Oct 1;31(42):4782-90. doi: 10.1016/j.vaccine.2013.08.002. Epub 2013 Aug 14.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Hepatitis B vaccine | Vaccine | 0.5 ml | Intramuscular |
| Subject | Measles, mumps, and rubella virus vaccine, live | Vaccine | 0.5 ml | Subcutaneous |
| Subject | Pneumococcal 7-valent Conjugate Vaccine | Vaccine | 0.5 ml | Intramuscular |
| Subject | Pneumococcal polysaccharide vaccine | Vaccine | 0.5 ml | Intramuscular |