drugset / Trial / NCT00257738

0804 GCC: MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck

NCT00257738

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Squamous Cell Carcinoma of the Head and Neck (SCCHN) is a devastating illness, the treatment of which is associated with significant morbidity. This type of cancer affects 43,000 individuals each year with an estimated survival rate of 50%. A potential treatment alternative for this patient population is the use of peptide-based immunotherapy. This clinical tial will be using a vaccines comprised on the Trojan peptides MAGE-A3 and HPV 16 to treat patients with Squamous Cell Carcinoma of the Head and Neck who have recurrent, progressive or metastatic SCCHN.

Timeline

Start
2005-11
Primary completion
2012-10
Completion
2012-10

Drugs

EvaluationDrugModalityDoseRoute
Subject MAGE-A3 Vaccine 500 ug Subcutaneous
Subject MAGE-A3 Vaccine 1000 ug Subcutaneous
Subject MAGE-A3 Vaccine 1500 ug Subcutaneous
Subject PELTOPEPIMUT-S Vaccine 500 ug Subcutaneous
Subject PELTOPEPIMUT-S Vaccine 1000 ug Subcutaneous
Subject PELTOPEPIMUT-S Vaccine 1500 ug Subcutaneous