drugset / Trial / NCT00257738
0804 GCC: MAGE-A3/HPV 16 Vaccine for Squamous Cell Carcinoma of the Head and Neck
Phase 1
Completed
17 enrolled
University of Maryland, Baltimore
National Institute of Dental and Craniofacial Research (NIDCR) · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
Squamous Cell Carcinoma of the Head and Neck (SCCHN) is a devastating illness, the treatment of which is associated with significant morbidity. This type of cancer affects 43,000 individuals each year with an estimated survival rate of 50%. A potential treatment alternative for this patient population is the use of peptide-based immunotherapy. This clinical tial will be using a vaccines comprised on the Trojan peptides MAGE-A3 and HPV 16 to treat patients with Squamous Cell Carcinoma of the Head and Neck who have recurrent, progressive or metastatic SCCHN.
Timeline
- Start
- 2005-11
- Primary completion
- 2012-10
- Completion
- 2012-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | MAGE-A3 | Vaccine | 500 ug | Subcutaneous |
| Subject | MAGE-A3 | Vaccine | 1000 ug | Subcutaneous |
| Subject | MAGE-A3 | Vaccine | 1500 ug | Subcutaneous |
| Subject | PELTOPEPIMUT-S | Vaccine | 500 ug | Subcutaneous |
| Subject | PELTOPEPIMUT-S | Vaccine | 1000 ug | Subcutaneous |
| Subject | PELTOPEPIMUT-S | Vaccine | 1500 ug | Subcutaneous |