Does the Rapid Intravenous Administration of Oxytocin After Delivery of the Baby Decrease the Bleeding During Cesarean Section in Women at Risk of Bleeding During Cesarean Section?

Summary

Oxytocin is normally given either rapidly into the vein (bolus) or put into an intravenous bag and administered more slowly, after delivery of the baby by cesarean section. Both of these methods are commonly used. To date there has been little research to demonstrate that one method of giving oxytocin is better than another in women who are more likely to bleed after delivery. The purpose of the study is to see whether a small bolus of oxytocin makes the uterus contract better to reduce bleeding and decreases the need to give additional oxytocin or more powerful drugs in women who are at risk for bleeding after delivery of their baby by cesarean section.

Timeline

Start

2005-11

Primary completion

2006-10

Completion

2012-12

Outcome

Missed primary endpoint

paper There was no difference in the need for additional uterotonic drugs in the first 24 hours between groups. PMID 20889945 ↗

paper did not alter the need for additional uterotonic drugs to prevent or treat postpartum hemorrhage in the first 24 hours PMID 20889945 ↗

Publications

• Results King KJ, Douglas MJ, Unger W, Wong A, King RA. Five unit bolus oxytocin at cesarean delivery in women at risk of atony: a randomized, double-blind, controlled trial. Anesth Analg. 2010 Dec;111(6):1460-6. doi: 10.1213/ANE.0b013e3181f8930a. Epub 2010 Oct 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxytocin	Peptide	5 iu	Intravenous

Indications

No indication recorded.