drugset
drugset / Trial / NCT00257894

Baclofen Effects on Smoking Urge and Withdrawal

NCT00257894 ↗

Phase 2 Terminated 41 enrolled VA Office of Research and Development
RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine whether baclofen is effective in reducing smoking urge, withdrawal, and reinforcement in moderate to heavy cigarette smokers.

Timeline

Start
2005-12
Primary completion
2008-12
Completion
2008-12

Outcome

Missed primary endpoint

Stopped (Enrollment): “Enrollment was completed with insufficient sample size for publishable results”

registry Baclofen Condition vs Placebo Condition; p = .57; ANOVA; NCT00257894 ↗

registry Baclofen Condition vs Placebo Condition; p = .21; ANOVA; NCT00257894 ↗

Drugs

EvaluationDrugModalityDoseRoute
Subject Baclofen Small molecule 20 mg Oral
Subject Baclofen Small molecule 40 mg Oral

Indications

nicotine dependence