drugset / Trial / NCT00258050
To Examine The Effects Of Lapatinib On Orally And Intravenously Administered Midazolam In Cancer Patients
RandomizedCrossoverOpen-labelTreatment
Summary
To characterize the effect of repeat oral dose of lapatinib treatment on the pharmacokinetics of a single oral and single intravenous dose of midazolam in adult cancer patients. Also to assess the safety and tolerability of chronic oral lapatinib therapy in cancer patients.
Timeline
- Start
- 2005-11-21
- Primary completion
- 2007-02-08
- Completion
- 2007-02-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lapatinib | Small molecule | 1500 mg | Oral |
| Subject | Midazolam | Small molecule | 3 mg | Oral |