Effect of Salicylate on Glucose Metabolism in Insulin Resistance States

Phase 1/2 Completed 17 enrolled Joslin Diabetes Center National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab National Institutes of Health (NIH) · collab

RandomizedParallel-groupQuadruple-blindOther

Summary

Data supports diet induced obesity leads to activation of the IKK/NF-kB inflamatory pathway and that chronic inflammation leads to insulin resistance and diabetes. In rodents, salicylates inhibit IKK/NF-kB and may improve insulin sensitivity. We will study if this is true in people.

Timeline

Start: 2000-01
Primary completion: 2008-05
Completion: 2008-05

Publications

Background Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2008 Feb;31(2):289-94. doi: 10.2337/dc07-1338. Epub 2007 Oct 24.
Background Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006 Jul;116(7):1793-801. doi: 10.1172/JCI29069.
Results Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May;1(1):36-43. doi: 10.1111/j.1752-8062.2008.00026.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Salsalate	Small molecule	4 g	—

Indications

No indication recorded.