drugset / Trial / NCT00266487
The Norwegian Vitamin Trial (NORVIT)
Completed
3750 enrolled
University of Tromso
Foundation to Promote Research into Functional Vitamin B12 Deficiency, Bergen, Norway · collabThe Council on Health and Rehabilitation, Norway · collabThe International Federation of Red Cross and Red Crescent Societies · collabThe Norwegian Council on Cardiovascular Disease · collabThe Research Council of Norway · collabThe Royal Norwegian Ministry of Health · collab
RandomizedFactorialDouble-blindTreatment
Summary
The purpose of this study is to examine whether the lowering of blood homocysteine levels by treatment with B vitamins can prevent cardiovascular disease
Timeline
- Start
- 1998-12
- Primary completion
- —
- Completion
- 2004-03
Publications
- Results Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K; NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006 Apr 13;354(15):1578-88. doi: 10.1056/NEJMoa055227. Epub 2006 Mar 12.
- Dhar I, Lysne V, Svingen GFT, Ueland PM, Gregory JF, Bonaa KH, Nygard OK. Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease. Am J Clin Nutr. 2019 Jun 1;109(6):1546-1554. doi: 10.1093/ajcn/nqy391.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pyridoxine | Unknown | 40 mg | — |
| Subject | Vitamin B12 | Other / unclassified | 0.4 mg | — |
| Subject | folic acid | Other / unclassified | 0.8 mg | — |