IMPACT Study (Improving Measurements of Persistence on "ACtonel" Treatment)

Summary

The primary objective of this study is to assess the impact of physician's reinforcement using bone marker data on the subject's compliance (at least 50% drug taken) and persistence on treatment after one year in postmenopausal osteoporotic women.

Timeline

Start

1999-08

Primary completion

2002-02

Completion

—

Outcome

Missed primary endpoint

paper persistence was unexpectedly high and was similar for both groups (RE-, 77%; RE+, 80%; P=0.160). PMID 17244788 ↗

Publications

• Results Delmas PD, Vrijens B, Eastell R, Roux C, Pols HA, Ringe JD, Grauer A, Cahall D, Watts NB; Improving Measurements of Persistence on Actonel Treatment (IMPACT) Investigators. Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab. 2007 Apr;92(4):1296-304. doi: 10.1210/jc.2006-1526. Epub 2007 Jan 23.

Drugs

Indications