A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When Natrecor (Nesiritide) is Added to Standard-Care Therapy, Compared to Administration of Placebo With Standard-Care Therapy

Summary

The purpose of this pilot study is to compare the clinical effects, safety profile, and economic impact of standard therapy plus Natrecor® (nesiritide, a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) to standard therapy plus placebo in patients who present to the Emergency Department with worsening congestive heart failure (CHF) and are treated in the Emergency Department /Observation Unit.

Timeline

Start

2001-01

Primary completion

—

Completion

2002-01

Publications

• Results Peacock WF 4th, Holland R, Gyarmathy R, Dunbar L, Klapholz M, Horton DP, de Lissovoy G, Emerman CL. Observation unit treatment of heart failure with nesiritide: results from the proaction trial. J Emerg Med. 2005 Oct;29(3):243-52. doi: 10.1016/j.jemermed.2005.01.024.

Drugs

Indications