drugset / Trial / NCT00287430
Growth Hormone Use in Adolescents and Adults With Cystic Fibrosis
Non-randomizedSingle-groupOpen-labelTreatment
Summary
We hypothesize that the anabolic effects of growth hormone (GH) will improve the clinical status of patients with CF by improving lean body mass, osteopenia, muscle strength, pulmonary function, and quality of life. We will recruit 40 malnourished CF patients for this 12-month study. All 40 patients will be treated with recombinant human growth hormone (rhGH). Each patient will serve as his/her own control by obtaining medical records for 6 months to 1 year prior to study enrollment or by completing 6 months of study without GH prior to being treated for 1 yr. with GH.
Timeline
- Start
- 2006-01
- Primary completion
- 2006-01
- Completion
- 2006-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Somatropin | Protein / enzyme biologic | 0.0125 mg/kg | Subcutaneous |
| Subject | Somatropin | Protein / enzyme biologic | 0.025 mg/kg | Subcutaneous |
| Subject | Somatropin | Protein / enzyme biologic | 0.3 mg/kg | Subcutaneous |
| Subject | Somatropin | Protein / enzyme biologic | 0.6 mg/kg | Subcutaneous |