Treatment of Hepatorenal Syndrome With Terlipressin Plus Albumin vs Albumin

Summary

Hepatorenal syndrome is a common complication of cirrhotic patients. The prognosis of patients with HRS is very poor. It have been demonstrated that vasoconstrictors agents (Terlipressin) plus albumin are effective in the reversal of the treatment. However, previous studies are pilot studies and they are not able to give information about an improvement in survival. This comparative randomized study was delineated to test the efficacy of terlipressin on survival.

Timeline

Start

2002-02

Primary completion

—

Completion

2006-09

Outcome

Outcome not reported

Stopped: “because in a preliminary analysis we would need 1000 patients per group to achieve significative differences in the main end point.”

Drugs

Indications