Uric Acid in Essential Hypertension in Children

Phase 2 Completed 30 enrolled National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Baylor University · collab

RandomizedCrossoverTriple-blindTreatment

Summary

The study is a randomized, double-blinded, placebo controlled, crossover trial of allopurinol for the treatment of children with newly diagnosed essential hypertension.

Timeline

Start: 2004-09
Primary completion: 2007-03
Completion: 2007-08

Outcome

Met primary endpoint

paper Twenty of the 30 participants achieved normal BP by casual and ambulatory criteria while taking allopurinol vs 1 participant while taking placebo (P < .001). PMID 18728266 ↗

paper treatment with allopurinol resulted in reduction of BP. PMID 18728266 ↗

Publications

Results Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008 Aug 27;300(8):924-32. doi: 10.1001/jama.300.8.924.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Allopurinol	Small molecule	200 mg	Oral