drugset / Trial / NCT00290121
Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics
Phase 4
Completed
25 enrolled
University of Montreal
Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · collabCentre de Recherche de l'Institut Universitaire de Geriatrie de Montreal · collabCentre de Recherche de l'Institut Universitaire en santé Mentale de Montréal · collabEli Lilly and Company · collab
Non-randomizedSingle-groupOpen-labelPrevention
Summary
The purpose of this study is to understand, with the use of functional magnetic resonance imaging, the neural correlates involved in appetite control and the mechanism of weight gain in patients with schizophrenia treated with atypical antipsychotics. We hypothesize that a difference in cerebral activations between weight gaining and non-weight gaining patients will be detected after four months of treatment with olanzapine.
Timeline
- Start
- 2006-09
- Primary completion
- 2008-06
- Completion
- 2008-06
Publications
- Orban P, Desseilles M, Mendrek A, Bourque J, Bellec P, Stip E. Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts. J Psychiatry Neurosci. 2017 Jan;42(1):17-26. doi: 10.1503/jpn.150247.
- Stip E, Lungu OV. Salience network and olanzapine in schizophrenia: implications for treatment in anorexia nervosa. Can J Psychiatry. 2015 Mar;60(3 Suppl 2):S35-9.
- Stip E, Lungu OV, Anselmo K, Letourneau G, Mendrek A, Stip B, Lipp O, Lalonde P, Bentaleb LA. Neural changes associated with appetite information processing in schizophrenic patients after 16 weeks of olanzapine treatment. Transl Psychiatry. 2012 Jun 19;2(6):e128. doi: 10.1038/tp.2012.53.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Olanzapine | Small molecule | — | — |