Prophylactic Administration of Vitamin C in Wrist Fractures

Summary

Complex Regional Pain Syndrome or posttraumatic dystrophy is a pain syndrome which develops after a trauma, surgery or for unknown reason. The incidence after wrist fractures varies in literature from 2 - 37%. The female sex is involved three times as much as the male sex. There is one study in literature which describes a prophylactic effect of vitamin C after wrist fractures. Goal of this study is to search for a dose dependent effect of vitamin C and to replicate these earlier findings.

Timeline

Start

2001-01

Primary completion

—

Completion

2005-12

Outcome

Met primary endpoint

paper RSD occurred in four (7%) wrists in the vitamin C group and 14 (22%) in the placebo group 15% (95% CI for differences 2-26). PMID 10636366 ↗

paper This prospective, double-blind study shows that vitamin C was associated with a lower risk of RSD after wrist fractures. PMID 10636366 ↗

Publications

• Results Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet. 1999 Dec 11;354(9195):2025-8. doi: 10.1016/S0140-6736(99)03059-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin C	Other / unclassified	200 mg	Oral
Subject	Vitamin C	Other / unclassified	500 mg	Oral
Subject	Vitamin C	Other / unclassified	1500 mg	Oral

Indications