Gradual vs. Abrupt Cessation Treatment for Smoking

Phase 2 Completed 750 enrolled University of Vermont National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This study tests whether stopping smoking by gradually cutting down first is more or less successful than stopping abruptly. We hypothesize that stopping by gradually cutting down first will produce more abstinence than stopping abruptly.

Timeline

Start: 2006-01
Primary completion: 2008-02
Completion: 2008-02

Publications

Results Hughes JR, Solomon LJ, Livingston AE, Callas PW, Peters EN. A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit. Drug Alcohol Depend. 2010 Sep 1;111(1-2):105-13. doi: 10.1016/j.drugalcdep.2010.04.007. Epub 2010 May 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotine	Unknown	2 mg	—
Subject	Nicotine	Unknown	4 mg	—

Indications

No indication recorded.