drugset / Trial / NCT00299208
Azithromycin Combination Therapy for Malaria
RandomizedParallel-groupOpen-labelTreatment
Summary
The goal of this study is to develop a safe, well tolerated, and highly efficacious azithromycin combination treatment for uncomplicated falciparum malaria. Azithromycin is a drug that has shown potential for malaria treatment. It will be combined with other malaria drugs currently approved for treatment in Thailand. About 120 people, ages 20-65, will be enrolled in Thailand. Participants will have severe cases of malaria and they will be hospitalized 28 days for treatment.
Timeline
- Start
- —
- Primary completion
- 2005-07
- Completion
- 2005-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Artesunate | Small molecule | 100 mg | — |
| Subject | Artesunate | Small molecule | 200 mg | — |
| Subject | Azithromycin | Small molecule | 500 mg | — |
| Subject | Azithromycin | Small molecule | 750 mg | — |
| Subject | Azithromycin | Small molecule | 1000 mg | — |
| Subject | Quinine | Small molecule | 10 mg/kg | — |