Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions

Phase 3 Completed 40 enrolled Assistance Publique - Hôpitaux de Paris

RandomizedParallel-groupDouble-blindTreatment

Summary

In children treated for intracranial lesions, the 2 factors of the obesity are : the location of the lesion (hypothalamic-pituitary region) and craniopharyngiomas

Timeline

Start: 2006-04
Primary completion: 2009-04
Completion: 2009-04

Outcome

Missed primary endpoint

paper The relative weight changes at 2 months in the DZX and placebo groups were -0.9 and -0.5%, respectively (P = nonsignificant). PMID 27603903 ↗

Publications

Brauner R, Serreau R, Souberbielle JC, Pouillot M, Grouazel S, Recasens C, Zerah M, Sainte-Rose C, Treluyer JM. Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial. J Clin Endocrinol Metab. 2016 Dec;101(12):4825-4833. doi: 10.1210/jc.2016-2126. Epub 2016 Sep 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Diazoxide	Unknown	4 mg/kg	—