drugset / Trial / NCT00306696
Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.
RandomizedParallel-groupOpen-labelTreatment
Summary
Study examining the effect of different diuretics on fluid retention in diabetics treated with rosiglitazone.
Timeline
- Start
- 2002-10
- Primary completion
- —
- Completion
- 2004-01
Outcome
Met primary endpoint
paper 0.87% (95% CI 0.03 to 1.71%) for RSG+HCTZ (P = 0.041) only. PMID 17093067 ↗
Publications
- Results Karalliedde J. Abstract (oral presentation). Management of Rosiglitazone Related Fluid Retention. Diabetes 2005; Vol 54, (suppl 1):Abstract number 81-OR
- Results Karalliedde J, Buckingham R, Starkie M, Lorand D, Stewart M, Viberti G; Rosiglitazone Fluid Retention Study Group. Effect of various diuretic treatments on rosiglitazone-induced fluid retention. J Am Soc Nephrol. 2006 Dec;17(12):3482-90. doi: 10.1681/ASN.2006060606. Epub 2006 Nov 8.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Furosemide | Other / unclassified | — | — |
| Subject | Hydrochlorothiazide | Unknown | — | — |
| Subject | Rosiglitazone | Small molecule | 4 mg | — |
| Subject | Spironolactone | Small molecule | — | — |