drugset / Trial / NCT00309855
Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
RandomizedCrossoverDouble-blindBasic science
Summary
This study is being done to understand how testosterone, the major male sex hormone, controls the pituitary gland's secretion of growth hormone (GH). GH is an important metabolic hormone, which controls sugar; fat and protein use in the body and maintains muscle strength and bone calcium content. Both testosterone and GH decline in older men. The age-related fall in these hormones probably contributes to relative frailty, reduced quality of life, bone loss, muscle wasting and impaired sexual function.
Timeline
- Start
- 2005-12
- Primary completion
- 2008-08
- Completion
- 2008-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Anastrozole | Other / unclassified | — | Oral |
| Subject | Dutasteride | Small molecule | — | Oral |
| Subject | Testosterone | Small molecule | — | Intramuscular |
Indications
No indication recorded.