Compare the Efficacy of Levocetirizine to Montelukast in Reducing Symptoms of SAR in Sensitive Subjects Exposed to Ragweed Pollen

Phase 3 Completed 403 enrolled UCB Pharma

RandomizedParallel-groupDouble-blindTreatment

Summary

To compare the clinical efficacy of levocetirizine 5 mg and montelukast 10 mg, administered once daily during two consecutive days, on symptoms of seasonal allergic rhinitis occurring in subjects exposed to ragweed pollen in an environmental exposure unit.

Timeline

Start: 2006-07
Primary completion: 2006-10
Completion: 2006-10

Outcome

Met primary endpoint

paper The MSC score in period 1 was progressively decreased to a significantly greater extent in the levocetirizine group compared with the montelukast and placebo groups. PMID 18814452 ↗

paper adjusted mean differences, -2.18 [95% confidence interval, -3.35 to -1.01; P < .001] PMID 18814452 ↗

Publications

Patel P, Patel D. Efficacy comparison of levocetirizine vs montelukast in ragweed sensitized patients. Ann Allergy Asthma Immunol. 2008 Sep;101(3):287-94. doi: 10.1016/S1081-1206(10)60494-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levocetirizine	Unknown	5 mg	—