Sexual Functioning Study With Antidepressants

Summary

Effects of two depression medication on sexual functioning

Timeline

Start

2004-09

Primary completion

2005-05

Completion

2005-05

Outcome

Met primary endpoint

paper primary dependent variable, the Changes in Sexual Functioning Questionnaire (self-report), increased for subjects receiving bupropion XL and decreased for those treated with venlafaxine XR PMID 16974189 ↗

paper mean change scores differed significantly between groups from week 2 onward. PMID 16974189 ↗

Publications

• Results Thase ME, Clayton AH, Haight BR, Thompson AH, Modell JG, Johnston JA. A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability. J Clin Psychopharmacol. 2006 Oct;26(5):482-8. doi: 10.1097/01.jcp.0000239790.83707.ab.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupropion	Small molecule	150 mg	—
Subject	Bupropion	Small molecule	450 mg	—
Subject	Venlafaxine	Small molecule	75 mg	—
Subject	Venlafaxine	Small molecule	225 mg	—

Indications