Safety of Ramelteon in Subjects With Chronic Obstructive Pulmonary Disease

Summary

The purpose of this study is to determine if ramelteon has respiratory depressant effects in subjects with moderate to severe chronic obstructive pulmonary disease.

Timeline

Start

2006-04

Primary completion

2006-11

Completion

2006-11

Outcome

Missed primary endpoint

paper No significant difference in SaO(2) for the entire night was observed with ramelteon vs placebo (92.2% vs 92.5%, P = 0.576). PMID 18584227 ↗

Publications

• Results Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep Breath. 2009 Mar;13(1):79-84. doi: 10.1007/s11325-008-0196-4. Epub 2008 Jun 27.

Drugs

Indications