Study to Determine if Atorvastatin Reduces Size and Stiffness of Muscle in the Left Ventricle of the Heart

Phase 3 Completed 22 enrolled University of Calgary Heart and Stroke Foundation of Canada · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine if a drug called atorvastatin will reduce the size and stiffness of the muscle in the left ventricle of the heart.

Timeline

Start: 2007-04
Primary completion: 2010-10
Completion: 2010-11

Outcome

Missed primary endpoint

paper After 12 months treatment, the LV masses in the placebo and atorvastatin groups were 196 ± 80 versus 206 ± 92 g (P = 0.80), respectively. PMID 28400935 ↗

paper In patients with HCM, atorvastatin did not cause LV mass regression or improvements in LV diastolic function. PMID 28400935 ↗

Publications

Hersi A, Giannoccaro JP, Howarth A, Exner D, Weeks S, Eitel I, Herman RC, Duff H, Ritchie D, Mcrae M, Sheldon R. Statin Induced Regression of Cardiomyopathy Trial: A Randomized, Placebo-controlled Double-blind Trial. Heart Views. 2016 Oct-Dec;17(4):129-135. doi: 10.4103/1995-705X.201784.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atorvastatin	Small molecule	80 mg	—