The Effect Of AVANDIA On The Late Asthmatic Response

Summary

This study is to investigate the effects of AVANDIA on the asthmatic response.

Timeline

Start

2005-07-22

Primary completion

2006-06-30

Completion

2006-06-30

Outcome

Met primary endpoint

paper The late asthmatic reaction (LAR) change from post saline FEV(1) from 4-10 hrs post allergen on day 28 was statistically significant PMID 19944580 ↗

paper Treatment with a PPARgamma agonist (rosiglitazone) was associated with a modest (15%) reduction in the late asthmatic reaction in the allergen challenge model of asthma. PMID 19944580 ↗

Publications

• Background This study has not been published in the scientific literature.
• Richards DB, Bareille P, Lindo EL, Quinn D, Farrow SN. Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: a randomised controlled trial. Respir Med. 2010 May;104(5):668-74. doi: 10.1016/j.rmed.2009.11.006. Epub 2009 Nov 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Rosiglitazone	Small molecule	4 mg	Oral

Indications