Azithromycin Treatment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and Tracheostomy

Summary

Aims of the study * to evaluate the rate of enteric gram negative bacteria colonization in tracheotomised COPD patients * to evaluate the effect of azithromycin long-term treatment on Pseudomonas aeruginosa colonization and colony counts, and on reduction of the number of exacerbations/hospitalisations, antibiotic courses and steroid use. * to evaluate the Quality of Life of patients treated and not treated with azithromycin, using a validate Italian version of St George questionnaire * to evaluate the rate of chronic colonization with atypical pathogens * to evaluate the safety and tolerability of a long-term treatment with azithromycin, including a survey on possible bacterial antibiotic resistance pattern variations

Timeline

Start

2004-10

Primary completion

—

Completion

2006-04

Publications

• Blasi F, Bonardi D, Aliberti S, Tarsia P, Confalonieri M, Amir O, Carone M, Di Marco F, Centanni S, Guffanti E. Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy. Pulm Pharmacol Ther. 2010 Jun;23(3):200-7. doi: 10.1016/j.pupt.2009.12.002. Epub 2009 Dec 16.

Drugs

Indications