Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer

Summary

This phase I/II trial is studying the side effects and best dose of isotretinoin when given together with vorinostat and to see how well they work in treating patients with advanced kidney cancer. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Isotretinoin may cause kidney cancer cells to look more like normal cells, and to grow and spread more slowly. Giving vorinostat together with isotretinoin may kill more tumor cells.

Timeline

Start

2006-03

Primary completion

2011-02

Completion

2014-05

Drugs

Indications