Seroquel STACK Study in Schizophrenic or Schizoaffective Subjects

Summary

The purpose of the study is to assess and compare the side effect profile, safety, tolerability and efficacy of schizophrenic or schizoaffective subjects non- or partially- responsive to 800 mg/day of quetiapine treated with either 800 mg/day or more than 800 mg/day of quetiapine during 8 weeks.

Timeline

Start

2003-10

Primary completion

—

Completion

2005-09

Outcome

Met primary endpoint

paper a value that was within the a priori limit of 16% defined as noninferiority. PMID 21733490 ↗

Publications

• Honer WG, MacEwan GW, Gendron A, Stip E, Labelle A, Williams R, Eriksson H; STACK Study Group. A randomized, double-blind, placebo-controlled study of the safety and tolerability of high-dose quetiapine in patients with persistent symptoms of schizophrenia or schizoaffective disorder. J Clin Psychiatry. 2012 Jan;73(1):13-20. doi: 10.4088/JCP.10m06194. Epub 2011 Jun 14.

Drugs

Indications