Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy

Phase 2 Completed 150 enrolled Massachusetts General Hospital National Institute of Mental Health (NIMH) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.

Timeline

Start: 2001-01
Primary completion: 2006-08
Completion: 2006-08

Publications

Grelotti DJ, Hammer GP, Dilley JW, Karasic DH, Sorensen JL, Bangsberg DR, Tsai AC. Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial. AIDS Care. 2017 Mar;29(3):273-279. doi: 10.1080/09540121.2016.1226479. Epub 2016 Sep 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fluoxetine	Small molecule	—	—

Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy

Summary

Timeline

Publications

Drugs

Indications