Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) Trial

Phase 3 Completed 120 enrolled National Center for Complementary and Integrative Health (NCCIH) University of Michigan · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

To determine the effect of hawthorn extract 450 mg bid vs. placebo, in addition to standard medical therapy in ambulatory patients with NYHA class II to IV chronic heart failure on submaximal exercise as measured by the 6-minute walk test

Timeline

Start: 2000-01
Primary completion: —
Completion: 2004-05

Outcome

Missed primary endpoint

paper There were no significant differences between groups in the change in 6 min walk distance (P = 0.61) PMID 19789403 ↗

Publications

Background Zick SM, Blume A, Aaronson KD. The prevalence and pattern of complementary and alternative supplement use in individuals with chronic heart failure. J Card Fail. 2005 Oct;11(8):586-9. doi: 10.1016/j.cardfail.2005.06.427.
Zick SM, Vautaw BM, Gillespie B, Aaronson KD. Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009 Oct;11(10):990-9. doi: 10.1093/eurjhf/hfp116.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Crataegus Special Extract WS 1442	Unknown	450 mg	—