Determining the Amount of Time Needed for Nelfinavir to Boost the Immune System in Adults

Phase 1 Completed 25 enrolled Mayo Clinic

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Our group has shown that HAART increases the thymic production of naïve T cells in the healthy adult, thereby boosting the immune system. We propose to investigate the amount of and length of Nelfinavir therapy necessary to increase those cells in adults. Subjects will be treated with Nelfinavir, and blood will be sampled at variable times to determine the immune response in peripheral blood.

Timeline

Start: 2005-10
Primary completion: 2007-10
Completion: 2007-10

Publications

Rizza SR, Tangalos EG, McClees MD, Strausbauch MA, Targonski PV, McKean DJ, Wettstein PJ, Badley AD. Nelfinavir monotherapy increases naive T-cell numbers in HIV-negative healthy young adults. Front Biosci. 2008 Jan 1;13:1605-9. doi: 10.2741/2784.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nelfinavir	Other / unclassified	1250 mg	Oral

Indications

No indication recorded.