Omega-3 Fatty Acids for High Triglycerides in HIV-infected Patients

Phase 4 Completed 48 enrolled Brown, Todd, M.D., Ph.D. GlaxoSmithKline · collab National Center for Complementary and Integrative Health (NCCIH) · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to evaluate the efficacy and safety of omega-3-fatty acids in HIV-infected patients with hypertriglyceridemia. In addition, we, the researchers, will evaluate the effect of omega-3 fatty acid administration of markers of bone turnover and inflammation.

Timeline

Start: 2006-10
Primary completion: 2010-04
Completion: 2010-04

Outcome

Met primary endpoint

registry analysis (superiority or other test); LOVAZA vs Placebo; p = 0.01; Wilcoxon (Mann-Whitney) NCT00346697 ↗

Publications

Results Metkus TS, Timpone J, Leaf D, Bidwell Goetz M, Harris WS, Brown TT. Omega-3 fatty acid therapy reduces triglycerides and interleukin-6 in hypertriglyeridemic HIV patients. HIV Med. 2013 Oct;14(9):530-9. doi: 10.1111/hiv.12046. Epub 2013 May 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Omega-3 fatty acid administration	Unknown	4 g	—