drugset / Trial / NCT00348985
PXD101 and Bortezomib in Treating Patients With Advanced Solid Tumors or Lymphomas
NaSingle-groupOpen-labelTreatment
Summary
This phase I trial is studying the side effects and best dose of PXD101 and bortezomib in treating patients with advanced solid tumors or lymphomas. PXD101 and bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PXD101 may also cause cancer cells to look more like normal cells, and to grow and spread more slowly. Giving PXD101 together with bortezomib may kill more cancer cells.
Timeline
- Start
- 2006-03
- Primary completion
- 2010-01
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Belinostat | Small molecule | — | Intravenous |
| Subject | Bortezomib | Small molecule | — | Intravenous |
Indications
Burkitt lymphoma
Hodgkins lymphoma
MALT lymphoma
Waldenstrom macroglobulinemia
adult T-cell leukemia/lymphoma
anaplastic large cell lymphoma
angioimmunoblastic T-cell lymphoma
central nervous system non-hodgkin lymphoma
chronic lymphocytic leukemia/small lymphocytic lymphoma
grade III lymphomatoid granulomatosis
intraocular lymphoma
large-cell immunoblastic lymphoma
mantle cell lymphoma
mycosis fungoides and variants
nodal marginal zone B-cell lymphoma
post-transplant lymphoproliferative disease
splenic marginal zone lymphoma