drugset / Trial / NCT00353652
Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension
Phase 4
Completed
166 enrolled
University of Texas Southwestern Medical Center
National Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedCrossoverSingle-blindTreatment
Summary
Thiazide medications are often prescribed for individuals with high blood pressure, but research has shown that they may increase an individual's risk of developing diabetes. While it is unknown exactly how thiazide causes this response, it is likely that the nervous system is somehow involved. This study will evaluate the role of the nervous system in sugar metabolism, as well as determine the effect of thiazide and other medications on individuals with high blood pressure.
Timeline
- Start
- 2005-01
- Primary completion
- 2013-01
- Completion
- 2013-01
Publications
- Raheja P, Price A, Wang Z, Arbique D, Adams-Huet B, Auchus RJ, Vongpatanasin W. Spironolactone prevents chlorthalidone-induced sympathetic activation and insulin resistance in hypertensive patients. Hypertension. 2012 Aug;60(2):319-25. doi: 10.1161/HYPERTENSIONAHA.112.194787. Epub 2012 Jun 25.
- Kontak AC, Wang Z, Arbique D, Adams-Huet B, Auchus RJ, Nesbitt SD, Victor RG, Vongpatanasin W. Reversible sympathetic overactivity in hypertensive patients with primary aldosteronism. J Clin Endocrinol Metab. 2010 Oct;95(10):4756-61. doi: 10.1210/jc.2010-0823. Epub 2010 Jul 21.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Chlorthalidone | Other / unclassified | 12.5 mg | — |
| Comparator | Chlorthalidone | Other / unclassified | 25 mg | — |
| Comparator | Irbesartan | Small molecule | 150 mg | — |
| Comparator | Spironolactone | Small molecule | 25 mg | — |
| Comparator | Spironolactone | Small molecule | 75 mg | — |