Aripiprazole and Effexor XR Drug Interaction Study

Phase 1 Completed 38 enrolled Otsuka Pharmaceutical Development & Commercialization, Inc.

Non-randomizedSingle-groupOpen-label

Summary

The purpose of this clinical research study is to learn whether aripiprazole has effect on the steady-state pharmacokinetics of venlafaxine in healthy subjects. The safety and tolerability of aripiprazole and venlafaxine co-administration will also be studied.

Timeline

Start: 2006-08
Primary completion: 2006-09
Completion: 2006-09

Publications

Boulton DW, Balch AH, Royzman K, Patel CG, Berman RM, Mallikaarjun S, Reeves RA. The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder. J Psychopharmacol. 2010 Apr;24(4):537-46. doi: 10.1177/0269881108096522. Epub 2008 Oct 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aripiprazole	Other / unclassified	20 mg	Oral
Subject	Venlafaxine	Small molecule	75 mg	Oral

Indications

No indication recorded.