A Study Of Lapatinib Versus Placebo Followed By Chemoradiation In Patients With Locally Advanced Head And Neck Cancer

Summary

This is a study comparing the activity of lapatinib versus placebo followed by chemoradiation. This study is designed to explore the effects of lapatinib monotherapy on apoptosis/necrosis, in pre-treatment and post-treatment tumour tissue samples in subjects with locally advanced squamous cell carcinoma of head and neck.

Timeline

Start

2006-03

Primary completion

2007-12

Completion

2007-12

Outcome

Missed primary endpoint

registry Placebo vs Lapatinib; p = .394; Mean Difference (Net) -1.7 (95% CI -5.50 to 2.19); ANCOVA NCT00371566 ↗

Drugs

Indications